Journal: Frontiers in Bioengineering and Biotechnology

Article Title: Biomechanical Impact of the Sclera on Corneal Deformation Response to an Air-Puff: A Finite-Element Study

doi: 10.3389/fbioe.2018.00210

Figure Lengend Snippet: (Left) Experimental setup for ex vivo studies on human donor eyes, showing a whole globe in the purpose-designed mount in front of the CorVis ST. (Right) A view of the human donor eye showing the 22-gauage needle inserted into the anterior chamber, used to set and maintain intraocular pressure.

Article Snippet: The CorVis ST air-puff velocity profile and corresponding pressure profile were simulated in COMSOL 5.2a (Figure ).

Techniques: Ex Vivo

Journal: Frontiers in Bioengineering and Biotechnology

Article Title: Biomechanical Impact of the Sclera on Corneal Deformation Response to an Air-Puff: A Finite-Element Study

doi: 10.3389/fbioe.2018.00210

Figure Lengend Snippet: Simulated CorVis ST air-puff velocity profile (left) and pressure profile (right) , which serves as the load on the anterior boundary of the globe. The simulation profiles agree within 2% of experimental measurements using hot-wire anemometry from Roberts et al. .

Article Snippet: The CorVis ST air-puff velocity profile and corresponding pressure profile were simulated in COMSOL 5.2a (Figure ).

Techniques:

Journal: Small (Weinheim an Der Bergstrasse, Germany)

Article Title: Vascular Microphysiological System for Investigating Endothelial Barrier Function During Organ Preservation and Reperfusion

doi: 10.1002/smll.202410168

Figure Lengend Snippet: 3D vascular MPS with variable wall shear stress (WSS) outfitted for electrical impedance spectroscopy (EIS). A) Schematic of PDMS MPS assembly with the electrode arrays positioned along the X‐axis. B) Photograph of vascular MPS instrumented with 40 µm width electrodes S1 through S4 at 4 regions within the tissue chamber at different wall shear stresses. Outline of cell chamber is marked with fiduciary black lines. Scale bar: 1 mm. C) Finite element analysis using COMSOL modeling showing: i) fluid velocity profiles in the tapered cell chamber; ii) WSS along the X ‐axis at Y = 0; and, iii) Y ‐axis WSS at X = 0.5, 3.5, and 6.5 mm with a media volumetric flowrate ( Q ) of 40 µL min −1 . The dotted lines in ii) correspond to X = 1, 3.5, and 6 mm. D) Confocal immunofluorescence images of human coronary artery ECs within the cell chamber of the vascular MPS. ECs organize according to shear stress: i) at point 1 in Ci, low shear stress cells are disorganized; and, ii) at point 2 in Ci, high shear stress cells are aligned with flow and have larger volume. Images on the right (red arrows) demonstrate ECs cover the surface area of the cell channel, clearly developing a 3D open lumen. VE‐Cadherin (green) and nuclei (DAPI/blue). Scale bar: 100 µm.

Article Snippet: WSS was taken from the shear rate from the 3D velocity profiles created by COMSOL multiplied by the dynamic viscosity.

Techniques: Shear, Impedance Spectroscopy, Immunofluorescence